交易须知
tetrandrine产品活性：tetrandrine (nsc-77037) 是一种双苯基异喹啉生物碱，抑制电压门控钙离子通道 (ica) 和 ca2+ 激活的钾离子通道。
研究领域：membrane transporter/ion channel
作用靶点：calcium channel | potassium channel
in vitro: the effects of tetrandrine (nsc-77037), a bis-benzyl-isoquinoline alkaloid, on voltage-gated ca2+ currents (ica) and on ca2+-activated k+ current (ik(ca)) and channels in isolated nerve terminals of the rat neurohypophysis are investigated using patch-clamp techniques. the non-inactivating component of ica is inhibited by external tetrandrine (nsc-77037) in a voltage- and dose-dependent manner, with an ic50=10.1μm. tetrandrine (nsc-77037) decreases the channel-open probability, within bursts, with an ic50=0.21 μm. to evaluate the effects of tetrandrine on hcc cells, huh7, hcclm9 and hep3b cells are treated with 0 (dmso), 0.5, 1, 2 or 4 μm of tetrandrine for 24 h. the cell proliferation assay indicates that tetrandrine exhibits almost no effect on the inhibition of hcc cell proliferation at 0.5-2 μm. however, tetrandrine (nsc-77037) inhibits hcc cell migration in a dose-dependent manner. furthermore, a wound-healing and transwell assay shows that 2 μm tetrandrine significantly inhibits hcc cell migration and invasion.
in vivo: to evaluate the effect of tetrandrine (nsc-77037) on the inhibition of tumor metastasis in vivo, hcclm9 subcutaneous tumor xenograft models is established with athymic nude mice. when the tumor volume reach approximately 50 mm3, nude mice are orally administered vehicle or tetrandrine (nsc-77037) (30 mg/kg) every other day for 37 days. tetrandrine (nsc-77037) treatment inhibits tumor growth by reducing the tumor volume and weight.
相关产品：fda-approved drug library plus | drug repurposing compound library plus | bioactive compound library plus | nigericin sodium salt | neomycin sulfate | verapamil hydrochloride | chlorpromazine hydrochloride | nifedipine | ionomycin | senicapoc | thapsigargin | acetylcholine chloride | glibenclamide | e-4031 | 4-aminopyridine | mibefradil dihydrochloride | ginsenoside rg3 | dofetilide | nimodipine | 20-hete | bay-k-8644 ((s)-(-)-) | cdn1163 | pap-1 | diltiazem hydrochloride | tolbutamide | amiodarone hydrochloride | minoxidil | tram-34 | dantrolene sodium hemiheptahydrate | diazoxide | flufenamic acid | ns-1619 | terfenadine
MedChemExpress LLC
郑先生
86-021-58955995
17321200539