calcitonin gene-related peptide (cgrp), labeled with 125i. cgrp binds calcitonin receptors.
cgrp (human), [125i]-, 10µci 产品详情
we offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (rias), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (bmax), dissociation constants (kd), association and dissociation rates (kon and koff), and inhibitor constants (ki) for a variety of receptors. we develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.
radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. for over 50 years, perkinelmer has been a leading supplier of new englａnd nuclear (nen) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
references for nex354:
meens, m., mattheij, n., van loenen, p., spijkers, l., lemkens, p., nelissen, j., compeer, m., alewijnse, a. and de mey, j. (2012), g-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. british journal of pharmacology, 166: 297–308.moore, e.l., gingell, j.j., kane, s.a., hay, d.l., salvatore, c.a. (2010), mapping the cgrp receptor ligａnd binding domain: tryptophan-84 of ramp1 is critical for agonist and antagonist binding. biochem biophys res commun, 394 (1): 141-145.
规格检测方法radiometric
新鲜的很多天third monday of each month
标签位置nominally labeled
分子量3912.0
产品品牌名称nen radiolabeled ligands
放射性同位素i-125
放射性核素125i
受体类型calcitonin
运输条件干冰
特殊订购信息this is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域diabetes, gastrointestinal
产品尺寸10 µci
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